Prof Elaine Dennison
MB BChir MA MSc PhD
Professor of Musculoskeletal Epidemiology and Honorary Consultant Rheumatologist
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Prof Elaine Dennison is Professor of Musculoskeletal Epidemiology and Honorary Consultant in Rheumatology within Medicine at the University of Southampton. Having worked as a Principal Investigator of the Hertfordshire Cohort Study for many years, her research interest centres around musculoskeletal aging, specifically osteoporosis, osteoarthritis and sarcopenia.
Prof Dennison has served on many national and international committees, including the International Osteoporosis Foundation Committee of Scientific Advisers, the Australian and New Zealand Bone Mineral Society Council, The British Society of Rheumatology Biologics Steering Committee (Chair), the British Society of Rheumatology Heberden Committee, The Royal Osteoporosis Society Grants Committee (Chair), the Versus Arthritis Research Committee and the Bone and Tooth Society Committee. She has received prestigious awards from the IOF (Pierre Meunier and Olof Johnell awards) and the British Society of Rheumatology (the Michael Mason award). Professor Dennison has a particular interest in academic training, and serves as NIHR IAT lead for Wessex and sits on the SAC Rheumatology as the academic representative.
Landmark publications:
1. Dennison EM, Syddall HE, Rodriguez S, Voropanov A, Day IN, Cooper C; Southampton Genetic Epidemiology Research Group. Polymorphism in the growth hormone gene, weight in infancy, and adult bone mass. J Clin Endocrinol Metab. 2004;89(10):4898-903
2. Repapi E et al, inc Dennison E. Nat Genet. 2010;42(1):36-44
3. Cole ZA, Harvey NC, Kim M, Ntani G, Robinson SM, Inskip HM, Godfrey KM,Cooper C, Dennison EM; Southampton Women's Survey Study Group. Increased fat mass is associated with increased bone size but reduced volumetric density in prepubertal children. Bone. 2012;50(2):562-7
4. Dennison EM, Compston JE, Flahive J, Siris ES, Gehlbach SH, Adachi JD, Boonen S, Chapurlat R, Díez-Pérez A, Anderson FA Jr, Hooven FH, LaCroix AZ, Lindsay R,Netelenbos JC, Pfeilschifter J, Rossini M, Roux C, Saag KG, Sambrook P, Silverman S, Watts NB, Greenspan SL, Premaor M, Cooper C; GLOW Investigators. Effect of co-morbidities on fracture risk: findings from the Global Longitudinal Study of Osteoporosis in Women (GLOW). Bone. 2012;50(6):1288-93
5. Edwards MH, Gregson CL, Patel HP, Jameson KA, Harvey NC, Sayer AA, Dennison EM, Cooper C. Muscle size, strength, and physical performance and their associations with bone structure in the Hertfordshire Cohort Study. J Bone Miner Res. 2013;28(11):2295-304
6. Dennison EM, Jameson KA, Edwards MH, Denison HJ, Aihie Sayer A, Cooper C. Peripheral quantitative computed tomography measures are associated with adult fracture risk: the Hertfordshire Cohort Study. Bone. 2014;64:13-7
7. Siviero P, Zambon S, Limongi F, Castell MV, Cooper C, Deeg DJ, Denkinger MD, Dennison EM, Edwards MH, Gesmundo A, Otero Á, Pedersen NL, Peter R, Queipo R, Timmermans EJ, van Schoor NM, Maggi S; EPOSA Research Group. How hand osteoarthritis, comorbidity and pain interact to determine functional limitation in older people: Observations from the Eposa study. Arthritis Rheumatol. 2016 ;68(11):2662-2670.
8. Edwards MH, Paccou J, Ward KA, Jameson KA, Moss C, Woolston J, Javaid MK, Cooper C, Dennison EM. The relationship of bone properties using high resolution peripheral quantitative computed tomography to radiographic components of hip osteoarthritis. Osteoarthritis Cartilage. 2017 ;25(9):1478-1483
9. Litwic AE, Compston JE, Wyman A, Siris ES, Gehlbach SH, Adachi JD, Chapurlat R, Díez-Pérez A, LaCroix AZ, Nieves JW, Netelenbos JC, Pfeilschifter J, Rossini M, Roux C, Saag KG, Silverman S, Watts NB, Greenspan SL, March L, Gregson CL, Cooper C, Dennison EM; Global Longitudinal Study of Osteoporosis in Women (GLOW) Investigators. Self-perception of fracture risk: what can it tell us? Osteoporos Int. 2017;28(12):3495-3500
10.Patel HP, Dawson A, Westbury LD, Hasnaoui G, Syddall HE, Shaw S, Sayer AA, Cooper C, Dennison EM. Muscle Mass, Muscle Morphology and Bone Health Among Community-Dwelling Older Men: Findings from the Hertfordshire Sarcopenia Study (HSS). Calcif Tissue Int. 2018;103(1):35-43
Major grants:
Cooper C, Dennison E, Harvey N, Ward K, Arden N, Javaid K, Prieto Alhambra D MRC (£3.81 million) 2021 – 2026 Bone and joint programme grant: musculoskeletal aging
Dennison EM. NIHR Southampton BRC Clinical fellowship (£138,144) 2019-21 Understanding the relationship between muscle and bone in older adults
Dennison EM, Cooper C, Clynes M. Academy of Medical Sciences (£30,000) 2019 – 2020 Does epigenetic age acceleration predict accelerated musculoskeletal aging
Dennison EM. NIHR Southampton BRC Clinical fellowship (£203,832) 2018 – 2021 Does a participant-led behaviour change intervention in community-dwelling, older adults lead to changes in lifestyle factors
Fuggle NR, Cooper C, Dennison EM. Dunhill Medical Foundation (£194,500) 2017 – 2021 Epigenetic age acceleration and aging
Cooper C, Dennison E, Harvey N, Ward K, Arden N, Javaid K, Prieto Alhambra D MRC (£4.1 million) 2017 – 2021 The developmental origins of osteoporotic fracture
Stevens M, Walker Bone K, Barker M, Dennison EM, Palmer K, Cooper C. (£124,000) 2016 -2020 What are the modifiable factors that would enable people to work to older ages in good health? Colt Foundation
Harvey NC and the MAVIDOS Study team, including EM Dennison (£363,000), 2010 – 2015 Follow up of the MAVIDOS trial. AR UK Cooper C, Dennison EM, Harvey NC, Arden N, Javaid MK.
MRC (£4.1 million) 2005 – 2010 The developmental origins of osteoporotic fracture,Dr Elaine Dennison Professor E Thomas, Professor DJP Barker.
MRC (£517,000) 1999 Fetal growth, adult lifestyle and chronic disease: a new resource for research,Prof C Cooper, Dr E Dennison, Dr N Harvey. MRC (£1.7 million) 1999 – 2005 Lifecourse determinants of osteoporotic fracture,
Professor C Cooper, Dr E Dennison. Wellcome Trust (£145,000) 1995 – 1999 Growth in infancy and osteoporosis