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Prof Myron Christodoulides

BSc, PhD

Professor of Bacteriology

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m.christodoulides@soton.ac.uk

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Myron Christodoulides is a graduate in microbiology from University College London and the University of Glasgow and a specialist in bacteriology. His key interests are broad and encompass the development of vaccines for bacterial infections and for neglected tropical diseases; drug discovery for novel antimicrobials; development of rapid diagnostic assays. Central to his research is multi- and inter-disciplinary collaboration with colleagues all over the world.

Landmark publications:


A candidate vaccine for   human visceral leishmaniasis based on a specific T cell epitope-containing   chimeric protein protects mice against Leishmania infantum infection. 

Lage DP,   Ribeiro PAF, Dias DS, Mendonça DVC, Ramos FF, Carvalho LM, de Oliveira D,   Steiner BT, Martins VT, Perin L, Machado AS, Santos TTO, Tavares GSV,   Oliveira-da-Silva JA, Oliveira JS, Roatt BM, Machado-de-Ávila RA, Teixeira   AL, Humbert MV, Coelho EAF, Christodoulides M. NPJ Vaccines. 2020 Aug   13;5:75. doi: 10.1038/s41541-020-00224-0. eCollection 2020. PMID: 32821440


Bactericidal Effect of   5-Mercapto-2-nitrobenzoic Acid-Coated Silver Nanoclusters against   Multidrug-Resistant Neisseria gonorrhoeae. 

Lucío MI,   Kyriazi ME, Hamilton J, Batista D, Sheppard A, Sams-Dodd E, Humbert MV,   Hussain I, Christodoulides M, Kanaras AG. ACS Appl Mater Interfaces.   2020 Jun 24;12(25):27994-28003. doi: 10.1021/acsami.0c06163. Epub 2020 Jun   12. PMID: 32530591


A rapid diagnostic test for   human Visceral Leishmaniasis using novel Leishmania antigens in a   Laser Direct-Write Lateral Flow Device. 

Humbert MV,   Costa LE, Katis I, Fonseca Ramos F, Sanchéz Machado A, Sones C, Ferraz Coelho   EA, Christodoulides M. Emerg Microbes Infect. 2019;8(1):1178-1185.   doi: 10.1080/22221751.2019.1635430. PMID: 31381478


Structure of the Recombinant   Neisseria gonorrhoeae Adhesin Complex Protein (rNg-ACP) and Generation   of Murine Antibodies with Bactericidal Activity against Gonococci. 

Almonacid-Mendoza   HL, Humbert MV, Dijokaite A, Cleary DW, Soo Y, Hung MC, Orr CM, Machelett MM,   Tews I, Christodoulides M. mSphere. 2018 Oct 10;3(5):e00331-18. doi:   10.1128/mSphere.00331-18. PMID: 30305317


Neisseria gonorrhoeae   employs two protein inhibitors to evade killing by human lysozyme. 

Ragland SA,   Humbert MV, Christodoulides M, Criss AK. PLoS Pathog. 2018 Jul   5;14(7):e1007080. doi: 10.1371/journal.ppat.1007080. eCollection 2018 Jul.   PMID: 29975775


Structure of the Neisseria   Adhesin Complex Protein (ACP) and its role as a novel lysozyme inhibitor. 

Humbert MV,   Awanye AM, Lian LY, Derrick JP, Christodoulides M. PLoS Pathog. 2017   Jun 29;13(6):e1006448. doi: 10.1371/journal.ppat.1006448. eCollection 2017   Jun. PMID: 28662181


Modified Profile of Matrix   Metalloproteinase 2 and 9 Production by Human Fallopian Tube Epithelial Cells   After Infection In Vitro With Neisseria gonorrhoeae. 

Rodas PI,   Pérez D, Jauffret C, González Y, Carreño C, Tapia CV, Osorio E, Velasquez LA,   Christodoulides M. J Infect Dis. 2017 Feb 1;215(3):452-455. doi:   10.1093/infdis/jiw568. PMID: 27932616


Major grants:


The Adhesin   Complex Protein (ACP) of Neisseria meningitidis

Christodoulides,   M. Medical Research Council: £346,521.00

1/04/14 →   31/03/17


Vaccine   studies on MIP protein of Neisseria meningitidis

Christodoulides,   M & Heckels, J. GlaxoSmithKline: £331,000.00

1/01/11 →   30/06/14


GSK   Collaboration Agreement Heckels, J. & Christodoulides, M.

GlaxoSmithKline:   £220,043.00 1/01/10 → 31/07/11


Gonococcal   infection of human fallopian tubes. 090301/Z/09/Z

Christodoulides,   M & Velasquez L. Wellcome Trust: £150,000

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