Prof Sumeet Mahajan
MSc, MTech, PhD, FRSC
Professor of Molecular Biophotonics and Imaging. Associate Director, Institute of Life Sciences. Head of Chemical Biology, School of Chemistry
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Prof Sumeet Mahajan is a Professor in Molecular Biophotonics & Imaging in Chemistry with a joint appointment in the Institute for Life Sciences at the University of Southampton. His group works at the life science interface with chemistry and photonics. The overarching aim of the research is to develop optical techniques and instrumentation to extract chemical information in a label-free manner from biological systems to understand disease processes for early, faster or more sensitive diagnostics for health and well-being. Exemplar application areas include biofilm and anti-microbial resistance detection and treatment and development of novel 3D imaging methods for understanding the pathogenesis of TB and IPF
Landmark publications:
1. Niall Hanrahan, Simon I. R. Lane, Peter Johnson, Konstantinos Bourdakos, Christopher Brereton, Robert A. Ridley, Elizabeth R. Davies, Neveen A. Hosny, Gunnar Spickermann, Robert Forster, Graeme Malcolm, Donna Davies, Mark G. Jones, Sumeet Mahajan*, "Label-free and Multimodal Second Harmonic Generation Light Sheet Microscopy", bioRxiv 2020.09.07.284703. https://doi.org/10.1101/2020.09.07.284703
2. Anna Huefner, Wei-Li Kuan, Sarah Mason, Sumeet Mahajan* and Roger Barker*, "Serum Raman Spectroscopy as a Diagnostic Tool in Patients with Huntington’s Disease", Chemical Science 2020, 11, 525-523. DOI:10.1039/C9SC03711J .
3. Mark G Jones et al. "Nanoscale dysregulation of collagen structure-function disrupts mechano-homeostasis and mediates pulmonary fibrosis", eLife 2018;7:e36354 DOI: 10.7554/eLife.36354
Major grants:
EPSRC (EP/V038036/1): Transformative Imaging for Quantitative Biology (TIQBio) Partnership. EPSRC contribution of £ 1,626,518 matched by an equal amount of Industrial Contribution (2021-2026)
EPSRC (EP/T020997/1): Lighting the Way to a Healthy Nation - Optical 'X-rays' for Walk Through Diagnosis & Therapy. Co-I and Southampton Lead with Prof Mark Bradley. Overall £6.2M with £2.4M to Southampton (2020-2025).
NanoChemBioVision – ERC Grant ( 638258): Next Generation Label-free Chemical Nanoscopy for Biomedical Applications. £1.5M (1.916M Euros), 2015-2020
Impact example:
Patented optical technologies for label-free microscopy are in the process of commercialisation.